Research, in the open.
Everything the lab publishes, in full. Confirmations and failures alike — a result that did not replicate is part of the record, not an omission from it.
- Replication reports
- 0
- Essays
- 4
4 papers matching these filters
Replication reports
0 papersNo replication reports match this view.
- August 31, 2026Revised September 16, 202637 min readEssayBioTechChemistryMedicineEngineering
Target Detection as the Rate-Limiting and Specificity-Limiting Step in CRISPR Genome Editing
CRISPR-Cas genome editing is usually described as a cutting technology. It is more accurately described as a search technology with a cutting terminus. The chemistry of phosphodiester hydrolysis is unremarkable; nucleases have performed it for billions of years. What is remarkabl…
Oleksii Vergunenko - August 29, 2026Revised August 29, 202615 min readEssayBioTechAIChemistryMedicineEngineering
From the Virtual Cell to the Human Digital Clone: A Specification for Whole-Body In Silico Physiology
Two research programs that developed largely in isolation — the AI virtual cell (bottom-up, data-driven models of cellular state and perturbation response) and the medical digital twin (top-down, physics-based models of organs and physiology) — are converging toward a shared obje…
Oleksii Vergunenko - August 29, 2026Revised September 16, 202626 min readEssayComputeBioTechPlatformAIMethods
The Verification Oracle Determines the Ceiling: Why Artificial Intelligence Advances Unevenly Across Mathematics, Physics, and Biology
Between mid-2025 and mid-2026, artificial intelligence systems moved from competition-level performance to contributions at the research frontier in mathematics, while in physics and biology the same underlying models were deployed largely as surrogates, controllers, and hypothes…
Oleksii Vergunenko - August 29, 2026Revised September 16, 202623 min readEssayBioTechRoboticsChemistryMaterialsEngineering
Engineered Living Materials as Robotic Integuments: Platforms, Specifications, and a Bandwidth Argument for Hybrid Skin
Engineered living materials (ELMs) — materials in which living cells are a load-bearing, functional component rather than a contaminant — have been proposed as a covering layer for robots. Three platforms have produced physical demonstrations: tissue-engineered mammalian dermis a…
Oleksii Vergunenko