The open library

Research, in the open.

Everything the lab publishes, in full. Confirmations and failures alike — a result that did not replicate is part of the record, not an omission from it.

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Essays
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2 papers matching these filters

  1. August 31, 2026Revised September 16, 202637 min read
    EssayBioTechChemistryMedicineEngineering

    Target Detection as the Rate-Limiting and Specificity-Limiting Step in CRISPR Genome Editing

    CRISPR-Cas genome editing is usually described as a cutting technology. It is more accurately described as a search technology with a cutting terminus. The chemistry of phosphodiester hydrolysis is unremarkable; nucleases have performed it for billions of years. What is remarkabl…

    Oleksii Vergunenko
  2. August 29, 2026Revised August 29, 202615 min read
    EssayBioTechAIChemistryMedicineEngineering

    From the Virtual Cell to the Human Digital Clone: A Specification for Whole-Body In Silico Physiology

    Two research programs that developed largely in isolation — the AI virtual cell (bottom-up, data-driven models of cellular state and perturbation response) and the medical digital twin (top-down, physics-based models of organs and physiology) — are converging toward a shared obje…

    Oleksii Vergunenko