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3 papers matching these filters
- August 31, 2026Revised September 16, 202637 min readEssayBioTechChemistryMedicineEngineering
Target Detection as the Rate-Limiting and Specificity-Limiting Step in CRISPR Genome Editing
CRISPR-Cas genome editing is usually described as a cutting technology. It is more accurately described as a search technology with a cutting terminus. The chemistry of phosphodiester hydrolysis is unremarkable; nucleases have performed it for billions of years. What is remarkabl…
Oleksii Vergunenko - August 29, 2026Revised August 29, 202615 min readEssayBioTechAIChemistryMedicineEngineering
From the Virtual Cell to the Human Digital Clone: A Specification for Whole-Body In Silico Physiology
Two research programs that developed largely in isolation — the AI virtual cell (bottom-up, data-driven models of cellular state and perturbation response) and the medical digital twin (top-down, physics-based models of organs and physiology) — are converging toward a shared obje…
Oleksii Vergunenko - August 29, 2026Revised September 16, 202623 min readEssayBioTechRoboticsChemistryMaterialsEngineering
Engineered Living Materials as Robotic Integuments: Platforms, Specifications, and a Bandwidth Argument for Hybrid Skin
Engineered living materials (ELMs) — materials in which living cells are a load-bearing, functional component rather than a contaminant — have been proposed as a covering layer for robots. Three platforms have produced physical demonstrations: tissue-engineered mammalian dermis a…
Oleksii Vergunenko