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  1. August 31, 2026Revised September 16, 202637 min read
    EssayBioTechChemistryMedicineEngineering

    Target Detection as the Rate-Limiting and Specificity-Limiting Step in CRISPR Genome Editing

    CRISPR-Cas genome editing is usually described as a cutting technology. It is more accurately described as a search technology with a cutting terminus. The chemistry of phosphodiester hydrolysis is unremarkable; nucleases have performed it for billions of years. What is remarkabl…

    Oleksii Vergunenko